The athlete entered the previous US Open as the 26th seed.
The tennis professional disclosed he thought about quitting the sport due to severe back issues during the season.
The 27-year-old, who has reached a career-high ranking of world number three, finished as runner-up to Novak Djokovic in the finals of the 2021 French Open and the 2023 Australian Open.
Currently placed as the world's 36th best player after a limited schedule since his second-round departure at the US Open in August, he stated continuous medical care has begun yielding encouraging progress.
"I'm most excited is to observe how my body responds during actual training with regard to my injury," said Tsitsipas.
"My primary worry was whether I could complete an encounter," the athlete continued, noting the injury plagued him "for the past six to eight months."
"I would wonder, 'Can I compete another contest pain-free?'"
"It was genuinely scary after the defeat in Flushing Meadows [to Germany's Daniel Altmaier]. I was unable to move for two days. That's when you start reconsidering your career's future."
He also reported satisfaction regarding the present treatment regimen following the completion of an extended period of pre-season training without any pain.
He is scheduled to compete for Greece in the United Cup, drawn against Naomi Osaka's Japan and the British team led by Emma Raducanu. The tournament takes place in Perth and Sydney from 2 to 11 January, the week preceding the Australian Open.
"The greatest victory next season would be to stop worrying over completing bouts," he expressed.
"It is incredibly encouraging to know you completed an off-season in good health – I wish for it to last. I aim to perform during the upcoming season and for the team championship.
"I have done the work. The crucial element is total belief in my ability to get back to where I was. I will attempt everything to achieve that."
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